The 10 Most Common Drugs that can make you fat

10 Most Common Drugs That Can Make You Fat

The use of modern prescription drugs is widely acknowledged to have significantly improved health promotion. In most cases, there are commonly prescribed drugs that can make you fat. Furthermore, all medications prescribed by doctors have side effects, and weight gain is a common effect. You can’t lose weight even if you eat well and exercise frequently. These drugs could be causing this weight gain.

Drugs that can Make you Fat

Despite weight gain being concerned to most patients, doctors frequently fail to mention it when prescribing medication. The fact that there are alternatives without this unpleasant side effect can make this situation even more frustrating. This article lists the ten most common drugs that can make you fat; they are prescribed frequently by doctors and have unpleasant side effects for patients.

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 Antidepressant Drugs

Drugs that can make you fat

Antidepressant drugs, when taken, can help relieve the symptoms of depression. Along with other anxiety disorders, they can aid in the treatment of seasonal affective disorder and social anxiety disorder. They function by resolving neurotransmitter chemical imbalances in the brain. It is best to seek a psychiatrist’s assistance and choose antidepressants like Zyban and Wellbutrin that don’t cause weight gain. Some of these drugs may energize you and make you feel more hungry. Some common examples of birth control pills include:

Hypertensive Drugs

These pills have a tendency to cause bloating and water retention, which can quickly lead to weight gain.

Diuretics can help you shed a small amount of water weight, but they can also make you gain weight because they cause your body to become thirsty after use. As a result, you eat more because your brain misinterprets your thirst for hunger. Beta-blocker medications, such as atenolol (Tenormin) and metoprolol (Lopressor, Toprol-XL), are more likely to cause weight gain. Typically, weight gain is not a side effect of more recent beta-blockers like carvedilol (Coreg). The good news is that weight gain usually stops after a few months of taking the medication.


Drugs that can make you fat

Corticosteroids lessen discomfort and inflammation. They differ from the steroids bodybuilders use to gain muscle. However, they can be administered orally, as an injection, as sprays, or as a cream. Additionally, the excessive use of these drugs may increase appetite and cause the body to store more fat, especially in the abdomen. The following are commonly used corticosteroid drugs:

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Drugs that can make you fat

Antihistamine drugs are used to treat typical allergy symptoms like a runny nose, watery eyes, hives, and sneezing. According to studies, the regular intake of certain antihistamines can result in increased body fat and waist circumference. This is due to the presence of diphenhydramine, which makes you sleepy immediately. 

The drugs function by preventing histamine, a chemical substance in the body that lessens allergy symptoms, from doing its job. However, antihistamines come in a variety of dosage forms, including tablets, eye drops, capsules, injections, liquids, and nasal sprays. Common antihistamines include:

Sleeping Pills are also Drugs That Can Make You Fat

Drugs that can make you fat

Basically, Ambien and other sleeping pills have the potential to increase body fat. These drugs force your body to relax but do not prevent brain activity. If your brain is still active, it will cause your body to act subconsciously, such as when you sleepwalk. However, it has been proven that patients can accomplish things such as cleaning, eating, and driving while sleepwalking. Additionally, after taking a sleeping pill, the patients may eat excessively each night without being aware of it. As you already know, excessive eating can cause a considerable increase in body fat.  

Insulin & Other Diabetes Drugs

Drugs that can make you fat

When taking an insulin drug to treat diabetes, it is possible that this drug may promote weight gain, especially because the hormone helps your body absorb glucose from the bloodstream. However, if sugar is not used by your body for energy after being absorbed from the bloodstream and pushed into cells, it will be turned into fat. Common diabetes drugs that may contribute to an increase in fat include:

Mood stabilizer

Drugs that can make you fat

According to the National Institute of Mental Health (NIMH) website, these drugs work directly by affecting the brain. However, this in turn can lead to changes in the metabolism and fat gain. They are psychiatric medications prescribed to treat mood disorders such as schizophrenia and bipolar disorder. These drugs include:

Epilepsy Drugs

Drugs that can make you fat

Most drugs that treat seizures have the potential to increase your appetite. It is important to understand that weight gain can occur when taking seizure drugs. However, if you believe the drug is not right for you, talk to your doctor about switching to epilepsy drugs that aid in weight loss or are weight neutral. Further, people with epilepsy who experience seizures can be treated with seizure drugs like Depakote (or valproic acid) and Depakene. Additionally, these specific drugs increase your appetite, which results in weight gain of at least 10 pounds. However, you can ask for lamotrigine (Lamictal), felbamate (Felbatrol), or topiramate (Topamax).

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Birth Control Pills

Drugs that can make you fat

These pills have a tendency to cause bloating and water retention, which can quickly lead to weight gain. Choosing a progestin or low-estrogen pill is a good idea. Theoretically, taking birth control pills might result in an increase in fluid retention. Additionally, they might result in gains in muscle or fat. However, some individuals might experience weight loss as a result of taking the medication. Common examples of birth control pills include: 

Migraine drugs

Drugs that can make you fat

These drugs contribute to the increase in body fat as they make you want to eat more. Basically, migraine drugs like oleanzipine and sodium valproate can lead to weight gain. However, avoid migraine medications like Depakene and Depakote, and consult your doctor about migraine drugs that cause weight loss or are weight neutral. Below are the common migraine medications that may cause an increase in body fat:

  • Elavil (amitriptyline)
  • Toprol-XL (metoprolol)
  • Ergomar (ergotamine)
  • Depakote (divalproex sodium)
  • Paxil (paroxetine)
  • Epival (sodium valproate)

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More drugs that can make you fat

There are more drugs that can cause an increase in body fat. Examples include most antibiotics and medications taken for hyperthyroidism. Before beginning any new medicine, discuss your concerns regarding weight gain with your doctor. Additionally, let your doctor know if you experience any new or strange symptoms after starting a drug. However, your doctor can determine if the drugs might be the issue. In that case, you can devise a strategy for addressing the side effect or attempt a different course of action.


In Conclusion, this is not meant to suggest that if your doctor prescribes medication, you shouldn’t take it. However, if you are taking drugs that can make you fat, it is a good idea to be aware of this beforehand and come up with a plan to try to reduce some of the weight gain side effects. Lastly, if you have to take a drug because it’s vital to your health, always ask your doctor about alternative medications that won’t make your body fat increase.

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